Which group consists of extremely powerful bronchoconstrictors and is involved with asthma and vascular collapse during anaphylaxis?

• A. Leukotrienes
• B. Prostaglandins
• C. Interleukins
• D. Histamines

Answer: (A)

Leukotrienes are lipid mediators released during allergic and inflammatory responses that directly cause strong, sustained bronchoconstriction and increased mucus production. This makes them a primary driver of asthma symptoms, where airway hyperreactivity is shaped by leukotriene activity. In anaphylaxis, leukotrienes contribute to vascular permeability and can worsen hypotension, helping drive vascular collapse along with other mediators. Prostaglandins and histamines do influence bronchial tone and vascular effects, but leukotrienes are the most potent and long-lasting bronchoconstrictors linked to both asthma and severe allergic reactions. Interleukins are cytokines that modulate inflammation rather than acting as direct bronchoconstrictors.